An AppDomain can be thought of as a lightweight process. Multiple AppDomains can exist inside a Win32 process. The primary purpose of the AppDomain is to isolate an application from other applications.

Win32 processes provide isolation by having distinct memory address spaces. This is effective, but it is expensive and doesn't scale well. The .NET runtime enforces AppDomain isolation by keeping control over the use of memory - all memory in the AppDomain is managed by the .NET runtime, so the runtime can ensure that AppDomains do not access each other's memory.